Introduction : Considering the transformations and developments of the contemporary societies, e-learning education plays a significant role in gaining access to education everywhere, at all time and for everyone. The aim of this study is to investigate the challenges of effective implementation of e-learning courses at Payame Noor University of Dehloran. Methods : The method used in this research is a descriptive study which employed the survey method. The statistical population comprises 1823 students at PNU of Dehloran in 2014 and 318 (109 males and 209 females) of them were selected as sample by using Morgan and Krejcie table. The tool for collecting data was a researcher-made questionnaire. The validity of the questionnaire was verified by experts and the reliability was found as 0.86 by using Cronbach’s Alpha. The data were analyzed via Kolmogorov-Smirnov test, sample T and Binomial proportions using the SPSS software, version 20. Results : The results illustrated that the behavioral, educational, technical challenges and challenges of human are necessary for effective implementation of e-learning courses in student’s view. Conclusions : In terms of infrastructure, promotion, facilitating and achieving the goals of Payame Noor University, it is necessary that policymakers and planners of Payame Noor University study the current situation, challenges and limitations of e-learning education before implementing e-learning courses. This can make them move toward the vision of PMU.