Introduction: E-learning can result in the promotion of efficiency in the educational processes. However, the development of E-Learning may fail to succeed if the users’ attitudes are not considered. The users’ attitudes are very effective in the adoption and use of E-learning. The purpose of this study was to determine the attitudes of faculty members of Kermanshah University of Medical Sciences on E-Learning.Materials and Methods: This cross-sectional study was conducted, using a stratified proportional random sampling. The participants consisted of the faculties members of Kermanshah University of Medical Sciences. The instrument for data collection was a researcher made questionnaire based on similar studies in two parts: part one with eleven background items, and part two with twelve attitude items. The validity of the questionnaire was approved, using experts’ comments and the reliability was found to be 0.73, using Cronbach's Alpha test. The collected data were analyzed by SPSS-21, using independent T-tests and ANOVA with α=0.05.Results: Maximum scores were 47.23 percent of the total score. Three items, “saving the students’ time”, “solving many problems of teaching” and “saving the teachers’ time” achieved the highest mean score, respectively. Only the faculty members with experience in E-learning education had better attitudes (p=0.003).Conclusion: The attitude of faculty members of Kermanshah University of Medical Sciences toward e-learning was not appropriate. Holding workshops in the field of E-learning by EDC can help to improve the condition.